SAP PP Consultant at Hybrid

The laboratory of Angiogenesisand Vascular Metabolism headed by Peter Carmeliet is one of the laboratories of theCenter for Cancer Biology (VIB-KU LeuvenCCB), a research department of VIB (FlandersInstitute for Biotechnology) located in the Oncology Department atthe KU Leuven (Campus Gasthuisberg, Leuven, Belgium).

The lab recently started a twin lab, thelaboratory for Angiogenesis and VascularHeterogeneity, at the Department of Biomedicine atAarhus University (Denmark) () whichis closely intertwined with the lab at the VIB-KU Leuven CCB ().Both the Leuven and new Aarhus lab function as one virtual lab, andsynergistically combine their joint forces and focus to studysimilar fundamental questions in vascular biology and angiogenesis,and to develop more efficiently new vascular

Carmeliet has an open position for a SeniorLaboratory Technician in the Aarhuslab. You will be trained first in the Leuven Oncethe training is completed you will move to the Aarhus lab totransfer your acquired knowledge & set up You will be thekey person to ensure a close linkbetween both You will continuously interact with and be trained by/informed via the Leuven The Department of Biomedicine at AarhusUniversity employs >450 people and covers a range ofresearch areas within Bio The infrastructure is well-developed withmodern laboratories, expertise units, and animal You will work inthe brand new Skou Building .

The Laboratory of Angiogenesis andVascular Metabolism headed by Peter Carmeliet focuses on thedevelopment of blood vessels(angiogenesis) andvascular heterogeneity in health anddisease, with the ultimate aim to identify novel therapeuticvascular-based

The Carmeliet lab explores theinnovative concept that endothelialcells (ECs), which line blood vessels, play a moreimportant role in immune responses than previously Recent projects,combining single-cell transcriptomics with bulk multi-omics(transcriptomics, (epi)-genomics, proteomics & metabolomics)revealed novel insights in EC heterogeneity in health and TheCarmeliet lab is now using these insights to design noveltherapeutic strategies, in part todevelop an alternative immunotherapy strategy for cancer (based ontargeting immunosuppressive mystery genes in ECs) and to developnovel immunotherapies for vascular disorders, characterized byvascular inflammation and EC dysfunction (diabetes,ischemia/reperfusion (also relevant for organ transplantationrejection), etc), based on targeting immunostimulatory genes in

The lab developed and uses innovativeintegrated approaches ( scRNA-sequencing, artificial intelligence(AI)/machine learning-based tools, multi-omics analysis) toefficiently discover new, biologically important, andtherapeutically attractive The ultimate goal is tobring promising validated scientific targets, upon translation, tothe level of drug development. In the meantime, theCarmeliet lab has successfully discovered and validated multiplemystery genes, some of which are now being considered for drug Theproject is conducted in a multidisciplinary environment at theinterface of an academic and clinical environment, where animalsurgery expertise and clinical samples are See below formore information concerning the research group and project

The lab is lookingfor a motivated Senior LaboratoryTechnician to support the discovery of newtherapeutic targets (using bulk/single cell multi-omics) and tobridge the valley of death (by functionally validating thesetargets). As part of our translational research team, you willinteract with a dynamic and experienced team of laboratory We arelooking for dynamic and flexible candidates, who are willing tostep into new adventures, dare to break new grounds outside oftheir comfort zone, are passionate about opportunities to bridgethe Valley of Death (see below), are not shy of diving into newfields, are primed and eager to become acquainted with newtechnologies (, artificial intelligence, drug target validation, ),and are prepared to go the extra Candidates should be able to workindependently, but in close consultation with Carmeliet and hissenior You are sufficiently mature to interact with othercolleagues via in-person and virtual meetings and to communicate ina professional

• Performing cell culture techniques: isolationand culture of endothelial cells and other cell types from surgicalsamples (human and mouse).
• Single-cell librarypreparation and
• Executing: western blotting,PCR, quantitative PCR, Fluorescence-activated cell sorting (FACS),
• Histology: fixation, embedding, cutting(vibratome or cryostat), and (immuno)staining of human and murine
• Imaging and analysis of tissue
• Assisting and/or performing animal
• Molecular biology assays (, viral transductionexperiments, siRNA transfection).
• Ordering ofproducts, consumables, and Follow-up Stock
• Keep laboratory and equipment clean andorganized to ensure safety in the
• Communicating and reporting laboratory resultsin a professional manner and in digital format ( excel) &participate in
• Support scientists daily,between multiple disciplines, and ensure
• Organize and troubleshoot practical work

• Candidates have aBachelor/ Master s degree in one of the following: laboratorytechnologies, biotechnology, biology, biomedicine, pharmacy, orrelated fields vascular/immunology expertise is an advantage, butnot
• You have solid experience as a laboratorytechnician in a research lab environment (>4-5 years).
• Proven experience in molecular biology, cellculture, biochemistry work, and/or other techniques
• Candidates are familiar with Microsoft Wordand
• Experience in histology, imaging, andanimal surgery will be considered an
• Extraadded values are: interest in (i) integrating single-cellmulti-omics; (ii) competence/interest in analysing and integratingomics- and clinical datasets; (iii) target validation assays
• You are interested and motivated to work onambitious projects in an open, dynamic, competitive, and driven
• You are flexible and willing to learn new
• You maintain excellent organizational skills;you can work in a team as well as
• You areaccurate and critical of your work and its implementation
• You have a strong ability to multi-task andmeet timelines
• Good English communicationskills, both oral and written, are

• The unique opportunity to work in a dynamic,multidisciplinary, and international team (in Aarhus-Leuven) wherepassion for innovation, team spirit, and continuous improvement ofnovel drug therapies, are part of our main
• Access to, and training in, state-of-the-arttechnologies in biomedical The Leuven lab has multiple corefacilities, with expertise in cell culture, FACS, metabolomics,(single cell) genomics/ transcriptomics, bioinformatics, animalsurgery, mouse transgenesis, immunohistochemistry & in situhybridisation (RNAscope), and imaging ().
• Youcan expect a varied job in an international
• Excellent training conditions within a team ofexperts where personal development is strongly Opportunities willcross your path, enabling you to keep on developing your
• We aim for a candidate with long-term career
• Starting as soon as

The Carmeliet labrecently started a twin lab at the Department of Biomedicine ofAarhus University in Aarhus, Denmark (https://), which is closelyintertwined with the lab at VIB-KU Leuven, Belgium (). The Leuvenand Aarhus lab will function as one virtual lab, andsynergistically combine their joint forces and focus to studysimilar fundamental questions in vascular biology, and to developmore efficiently new vascular There will be frequent interactionsand exchanges of junior/senior scientists and lab techniciansbetween both labs, offering unique opportunities formulti-disciplinary training at both Complementary settings andconditions at each location will create unprecedented extra-addedopportunities to increase the research output and translationaldevelopment quantitatively and qualitatively at a higher

The Aarhus and Leuven labs apply their expertise andtherapeutic focus to evaluate and to develop novel therapeuticconcepts into clinical development with the ambition to change thelife of patients with vasculature-related Standard gene modulationstrategies (conditional gene targeting) are exploited as well assophisticated novel disruptive high-throughput multi-omicsapproaches (bulk and scRNAseq, scATAC, ) and computationalmodelling and biology (AI/machine learning), both forhypothesis-generating and hypothesis-testing For instance, recentsuccessful efforts in generating a single-cell transcriptome atlasof ECs from various healthy and pathological (including tumor)tissues from preclinical models and clinical patient samplesrevealed the existence of previously unknown EC subtypes, includingECs with a putative immune-modulatory role (termed IMECs ). Inaddition, we developed novel AI-based tools to predict mysterygenes in ECs, which we use to develop alternative therapeutic

A major challenge of current medical researchis to translate the obtained high-profile insights into new Pharmais not interested in early-stage scientific results (even whenpublished in high-profile journals) because of the risk that thesecandidates are insufficiently validated for drug development, whileacademic scientists generally lack funds to provide more validationto bridge this gap ("the valley of death"). We aspire to not onlydiscover more new therapeutic targets but also to "bridge thevalley of death" in order to improve drug development by applyingin-house developed, less expensive novel approaches for targetvalidation at a rapid pace and Spinning out a start-up companybelongs to future options (as we did in the past with MontisBiosciences; see ).

Applications for thisposition should be submitted If you have questions about thisposition, please contact Peter Carmeliet: or Katie Van Geyte:.