Clinical Bioinformatician

Overview:
G42 Healthcare is committed to developing a world-class, sustainable healthcare sector in the UAE and wider region. At the forefront in the battle against the pandemic, G42 Healthcare partnered with Abu Dhabi authorities to develop a massive throughput laboratory in 14 days and spearheaded the world’s first Phase 3 clinical trial of COVID-19 inactivated vaccine. Beyond Covid-19, G42 Healthcare is also developing a program of activities to support the health of future generations - ranging from genomics, imaging and diagnostics to digitization programs, manufacturing and cutting-edge research.

**Responsibilities**:

- Able to develop, optimize and implement NGS data analysis for clinical diagnostic tests.
- Exploration, evaluation to identify optimal approaches for analysis of exomic, genomic, +/- transcriptomic data in clinical setting.
- Performs software compilation including NGS alignment, polymorphism identification, and +/- expression analysis.
- Extracts and filters variants for pathogenicity and verify them in different available databases like Clinvar and others with variant annotation.
- Provides and applies bioinformatics analysis for high throughput NGS results.
- Summarizes data analyses results as first draft of written report.
- Development of proper quality control, reporting and interpretation to allow DNAseq/ +/ - RNAseq to be interpreted rapidly.
- Development and implementation of an approach for validation and accreditation of the analyses.
- Develop and manage workflows to process large datasets such as those generated from nucleic acid sequencing platforms available at the Biogenix Laboratory.
- Analyze complex biological datasets using both established and novel methods.
- Maintain database records of experimental samples and results.
- Remain up-to-date about best practices and new technologies relevant to bioinformatics projects at G42.
- Generate Clinical reports of results and submit and discuss with Clinical Geneticist.
- Support other researcher efforts, when necessary.
- Maintain quality in all data analytics, development and service functions of the Biogenix Laboratory and ensure continuous quality improvement measures are in place.
- Conduct method evaluation/development and benchmarking as per standard policies and procedures to ensure that methods used are performing to international acreditation standards.
- Participate in implementing and observing ISO and CAP, ACMG standards and ensure maintenance of these standards in all activities.
- Complying with all safety, health and quality control programs and procedures as applicable.
- Maintaining the strictest confidence in relation to patient information whether formally or informally recorded.
- Ensuring that SOP (standard operation procedures) and Quality Assurance tests are maintained within all sections.
- Ensuring adequate documentation and communication of results, update on progress using approved and benchmarked software.
- Participating in training and education sessions.
- Participating in department programs/committees, and staff meetings, where applicable.
- Maintaining professional knowledge by attending lectures, seminars and on-line education units and creating an environment that encourages continuous learning for the Bioinformatics Team.
- Completing and maintaining all regulatory requirements including: licensure and certification and other mandatory training within established time frames.
- Adhere to Best Practices in all data analysis activities and contribute to improving on the content of the document.
Corresponding Activities performed by the role
- Analyse clinical genomics data and release Clinical Reports to be reviewd and signed by Clinical Geneticist and doctors.
- Collaborate with various internal teams including software, clinical, operations, research, and product development as assigned by team supervisor.
- Participate where applicable in the Biogenix Lab’s internal and external scientific research and publications.
- Designing, data gathering, processing, analysis and generating regular progress reports in the respect area of work and presentation of the results.
- Test new approaches and and tools, and build tools necessary for the performance of the respective duties.

Corresponding Activities performed by the role
- Complying consistently with facility policies, procedures and practices and ensuring alignment with facilities policies.
- Completing and maintaining regulatory requirements including: licensure and certification and other mandatory training within established time frames.
Maintaining confidentiality with regards to any information exchanged or received in the current capacity of role in accordance with facility policy.
Adhering to requirements of the Occupational Health and safety guidelines and infection control guidelines.
- Understanding and adhering to emergency preparedness plans/policies.
Recognizing the necessity of continuously developing skills and ac